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Background: Diabetes Mellitus (DM) triggers an extreme reaction of absolutely free-radicals. It boosts reactive oxygen species and lessens antioxidants standing as well as the β cell harm. Crystal clear kefir was employed for DM therapies, having said that it minimal biomolecular exploration of its bioactive roles. Investigation aimed to investigate the results of obvious kefir on the biomolecular character on the glycemic status of T2DM in Bandung. Methods: The randomized pretest-posttest control team was carried out by 106 T2DM individuals. Study was finished in many hospitals in Bandung and Cimahi, West Java from 2012–2013. Samples were divided randomly into 3 teams: (1) T2DM with HbA1c < 7 was fed an ordinary diet regime, supplemented with two hundred ml/day of crystal clear kefir, (2) T2DM with HbA1c > 7 fed typical diet plan and supplemented two hundred ml/working day by very clear kefir, (three) T2DM with HbA1c was fed a standard eating plan to be a Management team.